CARISTA - THUNDERSTORM ASTHMA

Creating A Risk assessment biomarker tool to prevent Seasonal and Thunderstorm Asthma

Study Population

Approximately 530 participants will be enrolled to monitor rhinitis, asthma symptoms and asthma exacerbations throughout 2 consecutive springtime seasons. 7 Victorian hospitals will be recruiting participants for this study.

Thunderstorm Asthma is a recurring public health emergency in South- Eastern Australia with increasing risks due to climate change.

CARISTA will test a novel approach to predict risk for seasonal allergic asthma to identify treatable traits for preventing seasonal allergic asthma exacerbations to reduce the recurrent annual health threat of seasonal and thunderstorm asthma, address community and healthcare provider concerns and uncertainty regarding preventative treatment and management.

Eligible subjects must be:

18 to 70 years of age

have a history of seasonal allergic rhinitis and/or are sensitised to ryegrass pollen.

Possess a smart phone or computer to record prospective symptom data collection

Study visits

The study involves a single on site visit for consent, enrolment and baseline assessments.

Study Requirements

Baseline Assessments include Lung function, FENO, blood sample, questionnaires

Daily symptom recording using Carista symptom monitoring platform throughout spring seasons 2025 and 2026

Clinical Trials Registry:

https://clinicaltrials.gov/study/NCT07055542